The plasma metabolome of long COVID-19 patients two years after infection

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In this study, our goal was to assess the plasma metabolome in a total of 108 samples collected from healthy controls, COVID-19 patients, and long COVID patients recruited in Mexico between 2020 and 2022. A questionnaire about symptoms persistence and self-reported comorbidities was assessed. Basic laboratory tests and CT scans were performed for long COVID patients. A targeted metabolomics approach using a combination of LC-MS/MS and FIA MS/MS was performed to quantify 108 metabolites. IL-17 and leptin concentrations were measured in long COVID patients by immunoenzymatic assay.

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