Diagnostic utility of gingival biopsy for pemphigus vulgaris and mucosa membrane pemphigoid: A 10-year cohort study

Published: 12 March 2024| Version 1 | DOI: 10.17632/95bzf9tnfv.1
Contributors:
Junjiang Liu,
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Description

Oral biopsy has been widely performed for the diagnosis of pemphigus vulgaris (PV) and mucosa membrane pemphigoid (MMP). It is more convenient to obtain normal-appearing mucosal tissues with high sensitivity of direct immunofluorescence (DIF) compared to the perilesional mucosa. This study was developed within a retrospective cohort between 2013 and 2023 including 84 PV patients and 74 MMP patients. The hematoxylin-eosin positivity of normal-appearing gingiva was 91.8% for PV and 73.7% for MMP. The DIF positivity of normal-appearing gingiva was 96.1% and 96.3% for PV and MMP, respectively. Compared with the perilesional mucosa (68.8%), the DIF positivity of normal-appearing gingiva (73.7%) was similar to each other in PV, while it was significantly higher (73.3% vs. 96.3%) in MMP (P = 0.02). Our results suggest that normal-appearing gingiva appears to be a good alternative biopsy site for the diagnosis of MMP and those pure gingival PV.

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Institutions

Sichuan University West China College of Stomatology

Categories

Cohort Study, Pemphigoid, Oral Mucosal Disease, Pemphigus, Gum (Oral Cavity), Diagnostic Accuracy

Funding

National Natural Science Foundation of China

82370963

National Natural Science Foundation of China

82071124

National Natural Science Foundation of China

82002884

National Natural Science Foundation of China

82301094

Central Government Guiding Local Science and Technology Development Foundation of Sichuan Province

2023ZYD0104

Natural Science Foundation of Sichuan Province

2023NSFSC0552

West China Hospital of Stomatology Interdisciplinary Curriculum

WCHSIC-23-06

Licence