Diagnostic utility of gingival biopsy for pemphigus vulgaris and mucosa membrane pemphigoid: A 10-year cohort study
Description
Oral biopsy has been widely performed for the diagnosis of pemphigus vulgaris (PV) and mucosa membrane pemphigoid (MMP). It is more convenient to obtain normal-appearing mucosal tissues with high sensitivity of direct immunofluorescence (DIF) compared to the perilesional mucosa. This study was developed within a retrospective cohort between 2013 and 2023 including 84 PV patients and 74 MMP patients. The hematoxylin-eosin positivity of normal-appearing gingiva was 91.8% for PV and 73.7% for MMP. The DIF positivity of normal-appearing gingiva was 96.1% and 96.3% for PV and MMP, respectively. Compared with the perilesional mucosa (68.8%), the DIF positivity of normal-appearing gingiva (73.7%) was similar to each other in PV, while it was significantly higher (73.3% vs. 96.3%) in MMP (P = 0.02). Our results suggest that normal-appearing gingiva appears to be a good alternative biopsy site for the diagnosis of MMP and those pure gingival PV.
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National Natural Science Foundation of China
82370963
National Natural Science Foundation of China
82071124
National Natural Science Foundation of China
82002884
National Natural Science Foundation of China
82301094
Central Government Guiding Local Science and Technology Development Foundation of Sichuan Province
2023ZYD0104
Natural Science Foundation of Sichuan Province
2023NSFSC0552
West China Hospital of Stomatology Interdisciplinary Curriculum
WCHSIC-23-06