Efficacy and safety of sequential treatment with cryotherapy followed by 1% topical tirbanibulin for actinic keratoses in organ transplant recipients: a randomized clinical trial

Name: Efficacy and safety of sequential treatment with cryotherapy followed by 1% topical tirbanibulin for actinic keratoses in organ transplant recipients: a randomized clinical trial
Creator: Ana Morelló Vicente
Published: 2025-07-21T08:56:18.743Z
Keywords: Cryotherapy, Actinic Keratosis, Squamous Cell Carcinoma, Patient with Solid Organ Transplantation, Topical Treatment

Morelló Vicente, Ana; Oteiza-Rius, Ines; Gómez-González, Elisa María; Carrera-Gabilondo, Ane; Marcos-Muñagorri, Deiane; Antoñanzas-Pérez, Javier; Rodríguez-Garijo, Nuria; Gil, María Pilar; España, Agustín; Nuñez-Córdoba, Jorge María; Salido-Vallejo, Rafael; Aguado-Gil, Leyre

doi:10.17632/9fm38ghtsn.1

Efficacy and safety of sequential treatment with cryotherapy followed by 1% topical tirbanibulin for actinic keratoses in organ transplant recipients: a randomized clinical trial

Published: 21 July 2025| Version 1 | DOI: 10.17632/9fm38ghtsn.1

Contributors:

Ana Morelló Vicente, Ines Oteiza-Rius, Elisa María Gómez-González, Ane Carrera-Gabilondo, Deiane Marcos-Muñagorri, Javier Antoñanzas-Pérez, Nuria Rodríguez-Garijo, María Pilar Gil, Agustín España, Jorge María Nuñez-Córdoba, Rafael Salido-Vallejo, Leyre Aguado-Gil

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Previous studies showed tirbanibulin’s efficacy in immunocompetent patients, but no data existed for solid organ transplant recipients. This study supports incorporating tirbanibulin in solid organ transplant recipients to treat the field of cancerization, improving AK clearance and reducing new lesions, suggesting its use beyond lesion-directed therapies in this population.

Efficacy and safety of sequential treatment with cryotherapy followed by 1% topical tirbanibulin for actinic keratoses in organ transplant recipients: a randomized clinical trial

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