Proteomics and bioinformatics Datasets: Terpenes as Modulators of Nociceptive Signaling: Behavioral and Molecular Insights from Caenorhabditis elegans

Description

This is the datasets used to support our study on the pharmacological effects of terpenes in C. elegans. The title of the article is :"Terpenes as Modulators of Nociceptive Signaling: Behavioral and Molecular Insights from Caenorhabditis elegans" Proteomic data were generated using a Thermo Scientific Q Exactive Plus Orbitrap Mass Spectrometer operating in TOP 12 DDA. Protein identification and quantification were performed using FragPipe (version 22.0) with the MSFragger search engine. Differential protein expression analysis was conducted using datasets generated by FragPipe (version 22.0) and its online tool FragPipe-Analyst Extracted parameters included the log₂ abundance ratio (experimental group vs. N2 control), corresponding p-values, p-adjusted values, and protein accession identifiers. Functional enrichment analysis was performed using ClusterProfiler, incorporating Gene Ontology (GO) biological process (BP) annotation and Reactome pathways.

Steps to reproduce

The experimental details can be found here : https://www.biorxiv.org/content/10.1101/2025.10.22.683951v1

Institutions

• Universite de Montreal

  QC, Montreal

Categories

Funders

• Natural Sciences and Engineering Research Council of Canada

  Ontario, Canada

  Grant ID: RGPIN-2020-05228

Licence