Supplemental figures, Khokhar et al. 2026
Description
Supplemental Figure 1. Reperfusion flow, relative to baseline flow, as predicted from changes in arterial diameter and capillary resistance. Colors indicate the flow. The X axis shows the baseline arterial resistance as fraction of the total resistance. The Y axis show the assumed degree of constriction, expressed as the arterial diameter during reperfusion normalized to the baseline diameter.S1A: flow calculations with unchanged capillary resistance during reperfusion, S1B and S1C: flow calculations in the case of a 2.5x (B) or 5x (C) increase in capillary resistance. Supplemental Figure 2. Full presentation of diameter measurements A) Changes in mean segment diameters relative to baseline at different time points grouped by Sex (n = 5 males, n = 5 females). B) Changes in mean segment diameters relative to baseline at different time points grouped per animal. C) Absolute changes in mean segment diameters at different time points. Diameters at all time points were significantly different from each other (n = 10 animals/ N = 197 vessel segments,*** p <0.001, GLM analysis). Supplemental Figure 3. Control groups A) Changes in mean segment diameters relative to baseline at different time points of animals in the sham surgery group (n = 4 animals/ N = 73 vessel segments,*** p <0.001, GLM analysis). B) Absolute change in mean segment diameters at Baseline 1 (24 hours post cranial window implantation) and Baseline 2 (48 hours post cranial window implantation). Diameters were not statistically significant between these time points (n = 4 animals/ N = 73 vessel segments, p > 0.05, GLM analysis). Supplementary video 1. Example video of flow arrest just before and after reperfusion. Supplementary video 2. Example video of slow flow during the occlusion phase. Supplementary video 3. Example video of retrograde flow being resolved following recanalization. Supplementary video 4. Example video of retrograde flow.