Comparative risk of reactivation of hepatitis B and C after treatment with biologics and targeted synthetic DMARDs in psoriasis and psoriatic arthritis: a 15-year multicenter cohort study

Published: 9 September 2025| Version 1 | DOI: 10.17632/b7kmhgbj9n.1
Contributors:
Hsien-Yi Chiu, Che-Chia Hsu, Tsen-Fang Tsai, Kuo-Lung Lai, Sung-Jen Hung, Nan-Lin Wu, Kai Che Wei, Tsu-Man Chiu, Shao-Hsuan Hsu, Ting-Yuan Lan, Chaw-Ning Lee, Ying-Ming Chiu, Rosaline Chung-yee Hui, Ching-Chi Chi, Chun-Bing Chen, Chao-Chun Yang, I-Lun Tseng,

Description

Supplementary data of study entitled Comparative risk of reactivation of hepatitis B and C after treatment with biologics and targeted synthetic DMARDs in psoriasis and psoriatic arthritis: a 15-year multicenter cohort study Supplementary Fig 1. Kaplan-Meier curves showing the probability of HBV reactivation in patients with psoriasis, stratified by risk factors Supplementary Fig 2. Kaplan-Meier curves showing the probability of HCV reactivation in patients with psoriasis, stratified by HCV viral load at baseline Supplementary Fig 3. Kaplan-Meier curves showing the sensitivity analysis of HBV reactivation risks for different subgroups. Supplementary Fig 4. Kaplan-Meier curves showing the sensitivity analysis of HCV reactivation risks for different subgroups. Supplementary Table I. Demographic features of the enrolled patients Supplementary Table II. Pairwise comparisons of the risk of HBV reactivation between the chronic HBV infection, occult, and resolved HBV groups Supplementary Table III. Crude incidence rate of HBV reactivation in patients with psoriasis, stratified by drug class Supplementary Table IV. Cox proportional hazards analysis of factors associated with HBV reactivation in patients with psoriasis receiving biologics Supplementary Table V. Pairwise comparisons of HBV reactivation risk across therapeutic classes Supplementary Table VI. Pairwise comparisons of the time to HBV reactivation across therapeutic classes Supplementary Table VII. Crude incidence rate of HCV reactivation in patients with psoriasis, stratified by drug class Supplementary Table VIII. Cox proportional hazards analysis of factors associated with HCV reactivation in patients with psoriasis receiving biologics Supplementary Table IX. Crude incidence rates of HBV reactivation in patients with psoriasis, stratified by drug class in the sensitivity analysis. Supplementary Table X. Pairwise comparisons of HBV reactivation risk across therapeutic classes in the sensitivity analysis. Supplementary Table XI. Cox proportional hazards analysis of factors associated with HBV reactivation in patients with psoriasis receiving biologics in the sensitivity analysis. Supplementary Table XII. Crude incidence rate of HCV reactivation in patients with psoriasis, stratified by drug class in the sensitivity analysis. Supplementary Table XIII. Cox proportional hazards analysis of factors associated with HCV reactivation in patients with psoriasis receiving biologics in the sensitivity analysis.

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Institutions

  • National Cheng Kung University Hospital
  • Taichung Veterans General Hospital
  • Mackay Memorial Hospital
  • Kaohsiung Veterans General Hospital
  • National Taiwan University Hospital Hsin-Chu Branch
  • National Taiwan University Hospital
  • Chung Shan Medical University Hospital
  • Tungs' Taichung MetroHarbor Hospital
  • National Taiwan University Hospital Yun Lin Branch
  • Chang Gung Memorial Hospital Linkou Branch
  • Hualien Tzu Chi Hospital

Categories

Biologic Agent, Hepatitis B, Hepatitis C, Immunosuppressive Therapy, Psoriasis

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