Association of DENND1A gene polymorphisms with polycystic ovary syndrome in Saudi Arabian women

Published: 12 November 2025| Version 1 | DOI: 10.17632/b9r6g98kr4.1
Contributor:
Jawaher Alzahrani

Description

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and a leading cause of infertility among women of reproductive age. Despite its increasing prevalence, the underlying molecular etiology remains poorly understood. Increasing evidence implicates genetic variants in DENND1A, a gene involved in endosomal trafficking and androgen biosynthesis regulation, in PCOS susceptibility. This study investigated the association of three intronic single-nucleotide polymorphisms (SNPs) (rs10818854, rs2479106, and rs10986105) within DENND1A with PCOS in Saudi Arabian women.

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Institutions

  • King Saud University

Categories

Sanger Sequencing

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