Coronavirus Spike Protein: West Bengal Variant B.1.618 triple mutation and possible consequences
Description
Mapping the mutations from the West Bengal variants, double mutant (B.1.617) and triple mutant (B.1.618), onto X-ray crystallographic structure of Receptor Binding Domain (RBD) and Cryo-EM structure of the Spike protein. Amino acids positions of E484K, D614G, and Y145-H146 are highlighted. The 3-minutes video is presented in Thai but I have provided a closed caption in English at this YouTube link (https://www.youtube.com/watch?v=vjmkRuJ-B8A).
Files
Steps to reproduce
1. Superposition of RBD X-ray structure onto Spike Protein Cryo-EM structure. 2. Show location of the African/UK variant B1.351 (N501Y+E484K+K417N) 3. Show E484Q (yellow) +L52R (cyan) location of the West Bengal double mutant (B.1.617). 3. Show E484K, D614G, Y145del,H146del (green area) location of the West Bengal double mutant (B.1.618).
Institutions
- Mahidol University
- Mahidol University Institute of Molecular Biosciences