Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability: Supplemental Material

Name: Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability: Supplemental Material
Creator: JoJo Holm
Published: 2026-05-13T21:32:11.906Z
Keywords: Proteomics, Immune Regulation, Microenvironment, Cutaneous T-Cell Lymphoma, Radiotherapy of Lymphoma, Spatial Transcriptomics

Holm, JoJo; Ostroff, Eleanor; Clarke, Lauren; De Jong, Katherine; Pang, Yanzhen; Hooper, Madeline; Evans, Spencer; Lu, Kurt; Rangel, Stephanie; Mittal, Bharat; Guitart, Joan; Weichselbaum, Ralph; Ren, Ziyou; Zhou, Xiaolong

doi:10.17632/c2hxjk8ws5.1

Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability: Supplemental Material

Published: 13 May 2026| Version 1 | DOI: 10.17632/c2hxjk8ws5.1

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This supplemental data supports our research letter which demonstrates that cutaneous T-cell lymphoma (CTCL) tumors undergoing radiotherapy (RT) experience an immune shift from malignant inflammation to wound healing. Eight CTCL patients were followed through a course of low-dose RT wherein punch biopsies and tape strips were used to analyse the transcriptome and proteome of CTCL tumors before and after RT.

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Northwestern University
Illinois, Evanston

Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability: Supplemental Material

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