CKS2 is overexpressed in high-grade and recurrent meningiomas and functions as an oncogene via the CKS2/miR-26a/miR-101a axis
Description
This data includes lists of the commonly dysregulated genes among different grades of meningioma (Grade 3 vs Grade 1; Grade 3 vs Grade 2; Grade 2 vs Grade 1) and recurrent vs non-recurrent cases in at least 2 or more datasets, obtained after multi-GEO dataset analysis including 6 datasets. Four of these studies (GSE43290, GSE16581, GSE16181, and GSE74385) were microarray-based, whereas two (GSE101638 and GSE183653) used high-throughput sequencing for gene expression analysis.
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We performed a series of analyses on data retrieved from 6 GEO datasets to identify key genes dysregulated in different meningioma grades and between recurrent and non-recurrent meningiomas. We performed a multistep analysis to identify DEGs (|Log2FC| > 1 and p(adj) < 0.05) among different tumor grades and recurrent vs non-recurrent meningiomas in each of the six GEO datasets. We next identified the significant DEGs common in two or more GEO datasets for each comparison. We then identified “key” dysregulated genes (key DEGs), defined as common in 2 or more datasets with consistent differential expression patterns among different grades as well as in recurrent vs non-recurrent meningioma.