Engineered core-shell immunomodulators for dual immune activation and sustained anti-MRSA protection via macrophage metabolic reprogramming
Description
Artificial biofilm-coated nucleoshell immunomodulator (LM@HiSeL) is a novel immunomodulator designed to achieve precise modulation of the body's immune system through its unique nucleoshell structure and biofilm coating, in order to enhance the body's defenses against pathogens (e.g., methicillin-resistant Staphylococcus aureus, MRSA). This database aims to systematically document the comprehensive properties of LM@HiSeL, including key information on its characterization, safety, stability, bioactivity assessment, and mechanism of action, so as to provide data support for subsequent research and clinical applications.
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In this study, the artificial biofilm-coated core-shell immunomodulator (LM@HiSeL) was firstly prepared, followed by comprehensive characterization (TEM, DLS, FTIR, etc.), safety assessment, stability analysis, determination of oxidative stress indexes, and evaluation of rapid cross-protective properties, and the potential mechanism of its action was revealed by in vitro, in vivo, and in vitro models. In addition, transcriptome assay further elucidated the mechanism of action of LM@HiSeL, and also verified its long-lasting protective effect against methicillin-resistant Staphylococcus aureus (MRSA).