HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease

Published: 21 April 2023| Version 1 | DOI: 10.17632/ck9f9rkdvw.1
Contributors:
, Matthew Vesely

Description

Human DLE demonstrates expression of HIF1- and cytotoxic molecules including granzyme B in the DLE lymphocytic infiltrate. Normalized gene expression per region of interest (ROI) in DLE or normal control skin (n = 3 patients, 3 ROIs per patient) as characterized by Nanostring GeoMx Digital Spatial Profiling. ROIs were selected to include T cell rich infiltrate. Cancer Transcriptome Atlas RNA probe set used.

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Institutions

Yale University School of Medicine

Categories

Skin, Lupus Erythematosus

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