Mechanosensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology

Description

Mitral regurgitation (MR) pathophysiology involves increased serotonin (5-HT) receptor (HTR) expression and signalling, together with reduced 5-HT transporter (SLC6A4) expression in mitral valve interstitial cells (MVIC). The mechanosensitive calcium channels, PIEZO1 and PIEZO2, regulate cellular responses to a variety of mechanical conditions; however, PIEZO1 and PIEZO2 have not been studied in MR. We investigated the hypothesis that PIEZO1 and PIEZO2 mediate, through 5-HT mechanisms, both homeostasis in normal mitral valves (nMV) and in the pathophysiology of MR.

Institutions

• Children's Hospital of Philadelphia

  Pennsylvania, Philadelphia

Categories

Funders

• American Heart Association

  Texas, Dallas

Licence