Dataset for Real-time monitoring of attenuated cytomegalovirus using Raman spectroscopy allows non-destructive characterization during flow
Published: 6 August 2025| Version 1 | DOI: 10.17632/cs888gdmp4.1
Contributors:
Shreya Milind Athalye, , Ehsan Esmaili, Miad Boodaghidizaji, Jessica Raffaele, Vidhya Salvamani, Joseph P. Smith, Tiago Matos, Richard R. Rustandi, Arezoo Ardekani, Mohit VermaDescription
We demonstrated the application of Raman spectroscopy to predict the concentration of viral samples in flow conditions. Our study demonstrates that our Raman spectroscopy-based PAT tool can detect cytomegalovirus (CMV) even at high (1000 µm/s) flow conditions. Also, SDS-PAGE and Dynamic light scattering methods confirm the stability of viral particles after laser exposure. In this dataset, we've included the raw and processed data files associated with the manuscript.
Files
Institutions
- Purdue UniversityIN, West Lafayette
Categories
Raman Spectroscopy, Process Analytical Technology, Cytomegalovirus, Advanced Manufacturing
Funders
- National Institute for Innovation in Manufacturing BiopharmaceuticalsDelaware, United States
- National Institute of Standards and TechnologyMaryland, United States
- Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.