Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease

Name: Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease
Creator: Shijia Rao
Published: 2019-07-10T05:26:37.771Z
Keywords: Immunology, Dermatology, Pathology

Rao, Shijia; Li, Qianwen; Wu, Haijing; Zhao, Ming; Wang, Alun; Zhang, Guiying; Li, Ji; Lu, Lixia; Shi, Wei; Lu, Qianjin

doi:10.17632/csp4939d3j.1

Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease

Published: 10 July 2019| Version 1 | DOI: 10.17632/csp4939d3j.1

Contributors:

Shijia Rao, Qianwen Li, Haijing Wu, Ming Zhao, Alun Wang, Guiying Zhang, Ji Li, Lixia Lu, Wei Shi, Qianjin Lu

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The unique pathological manifestation was presented in all APSEs patients but could hardly be found in ESEs patients. Besides CD11b+ and CD68+ cells, there were more CD4+ T-cells infiltrate in the dermis of APSEs than in ESEs. IL-1β and IFN-γ were specifically expressed in the upper third of the epidermis, juxtaposition to the loci of the necrotic keratinocytes.

Juxtaposition of IL-1β and IFN-γ expression and apoptosis of keratinocytes in adult-onset still’s disease

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