Bioinspired Selenium Co-Precipitated Calcium Phosphate/PLCL with Acid-Buffering, Multi-Ion Release for Osteosarcoma Cell Suppression and Osteogenesis

Description

We hypothesized that co-precipitating selenium (Se) into calcium phosphate (CaP) during biomimetic mineralization, while serving as a multifunctional ionic reservoir when blended with p Poly(L-lactide-co-ε-caprolactone) (PLCL). Specifically, this Se@CaP-PLCL composite is designed to buffer the acidic degradation products of PLCL, provide sustained dual-action multi-ion delivery (Se, Ca, P), suppress osteosarcoma (OS) cell viability and migration, and simultaneously promote osteogenic differentiation and mineralization for post-surgical bone defect repair.

Institutions

• Zhejiang University

  Zhejiang, Hangzhou

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