Markov chain models for tissue regulatory T cell cellular kinetics and dwell times

Published: 12 April 2024| Version 1 | DOI: 10.17632/czhfj4g6vb.1
Contributors:
,
,
, Adrian Liston

Description

CD45.1 mice were parabiosed to CD45.2 mice. Pairs of parabiotic animals were sacrificed and perfused at weeks 1, 2, 4, 8, and 12 for tissue analysis by flow cytometry (n=11,12,18,16,14). Markov chains were built to model the changes in cell state and tissue exchange, with each tissue built using a model containing the tissue, blood, and combined other tissues. Full code for analysis: https://github.com/gergelits/markov_chain_tissue_treg

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Institutions

Babraham Institute, University of Cambridge, VIB KU Leuven Center for Brain and Disease Research

Categories

Immunology, Computational Biology

Funding

Wellcome Trust

222442/A/21/Z

European Research Council

TissueTreg

Licence