Markov chain models for tissue regulatory T cell cellular kinetics and dwell times
Published: 12 April 2024| Version 1 | DOI: 10.17632/czhfj4g6vb.1
Contributors:
, , , Description
CD45.1 mice were parabiosed to CD45.2 mice. Pairs of parabiotic animals were sacrificed and perfused at weeks 1, 2, 4, 8, and 12 for tissue analysis by flow cytometry (n=11,12,18,16,14). Markov chains were built to model the changes in cell state and tissue exchange, with each tissue built using a model containing the tissue, blood, and combined other tissues. Full code for analysis: https://github.com/gergelits/markov_chain_tissue_treg
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Institutions
Babraham Institute, University of Cambridge, VIB KU Leuven Center for Brain and Disease Research
Categories
Immunology, Computational Biology
Funding
Wellcome Trust
222442/A/21/Z
European Research Council
TissueTreg