Efficacy of 0.25% Timolol Gel in Healing Surgical Open Wounds: A Randomized Clinical Trial
Published: 10 September 2025| Version 1 | DOI: 10.17632/czy3r8b8vm.1
Contributors:
Nancy Anabaraonye, Nina Ran, Emily Karn, Fadi Murad, David Stein, Emily Ruiz, Chrysalyne Schmults, Abigail WaldmanDescription
In this clinical trial, we evaluate whether topical timolol 0.25% gel improves re-epithelialization when applied to surgical wounds healing by secondary intention. We recruited patients undergoing Mohs surgery and randomized 86 patients to timolol or standard of care. Study participants applied timolol or Vaseline to their surgical wounds and provided standardized photographs over the course of 24 weeks, which were scored by two blinded investigators. We evaluated time to re-epithelialization and observed no difference in this outcome between the timolol cohort and the standard of care cohort.
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Categories
Dermatology, Topical Agent, Wound Healing, Clinical Research, Mohs Surgery