Metabolites differentiating controls from PCOS participants
Description
Supplementary Table S1. VIP list obtained from OPLS-DA analysis of PCOS and controls Supplementary table S2. Metabolites differentiating controls from PCOS participants
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Tandem mass spectrometry was performed for targeted metabolomics of plasma samples using Biocrates MxP® Quant 500 Kit (Biocrates, Innsbruck, Austria) at the Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM). FIA-MS/MS was utilized to measure lipids using a 5500 QTRAP® instrument with an ESI source (AB Sciex, Darmstadt, Germany). LC-MS/MS utilizing the same 5500 QTRAP® instrument was used for measuring small molecules as described previously [17]. Appropriate MS software (Sciex Analyst®) was used to quantify data that was then imported into Biocrates MetIDQ™ software for calculation of analyte concentrations, assessment and compilation of data.