ROR1-PI3K/AKT signaling drives adaptive resistance to cell cycle blockade in TP53 mutated ovarian cancer

Published: 14 January 2026| Version 1 | DOI: 10.17632/dd6bvtrv9b.1
Contributors:
,
,
,
,
, Daniela Ungureanu

Description

We developed long-term resistant pre-clinical models to two complementary drugs: adavosertib (ADA) and paclitaxel (PTX). Through multiomics functional profiling we identified distinct transcriptomic and morphological changes in the ovarian cancer resistant models. - seurat_counts.csv.gz: raw counts for sc-data - seurat_metadata.csv.gz: metadata for sc-data - CellPainting_raw_data.zip: Cell Painting features extracted with CellProfiler - SourceData_FigureS3.zip: Source data for figure S3 - SourceData_FigureS4.zip: Source data for figure S4 - SourceData_FigureS6.zip: Source data for figure S6

Files

Steps to reproduce

To fully utilize the dataset linked to this research article, we kindly request you to thoroughly review the Methods section and our GitHub repository.

Institutions

  • Oulun Yliopisto

Categories

Ovarian Cancer, Single-Cell Transcriptomics

Funders

Related Links

Software
https://github.com/ungureanulab/OC-resistance-profiling
compiles this dataset

Licence