Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway

Published: 29 September 2023| Version 1 | DOI: 10.17632/dht9r4n388.1
Contributors:
Jing Zhang, Daniel McGrail,

Description

Immune checkpoint blockade (ICB) has revolutionized cancer treatment. However, ICB alone has demonstrated only benefit in a small subset of patients with breast cancer. We here reported that the tumoral cytosolic ssDNA is associated with tumor-infiltrating lymphocyte in patients with triple negative breast cancer. TREX1 deficiency triggered a STING-independent innate immune response via DDX3X. Cytosolic ssDNA accumulation in tumors due to TREX1 deletion is sufficient to drastically improve the efficacy of ICB.

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Institutions

University of Texas MD Anderson Cancer Center

Categories

RNA Sequencing

Funding

National Institutes of Health

R01CA247862

National Institutes of Health

R00CA240689

Licence