Gut microbiota metabolite IPA released by Akk ameliorates DIC by regulating PPARα-dependent mitochondrial biogenesis

Published: 5 September 2024| Version 1 | DOI: 10.17632/dk8hw2m7gg.1
Contributors:
,
, Zuoquan Zhong

Description

AKK supplementation increased serum levels of the tryptophan metabolite indole-3-propionic acid (IPA), which binds to the cardiac aryl hydrocarbon receptor (AhR), leading to the activation of the PPARα/PGC1α signaling pathway. These findings highlight the potential of AKK as a probiotic in mitigating DIC.

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Institutions

Shaoxing People's Hospital

Categories

Gut Microbiome, Cardiology

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