Mendelian Randomized study for Atopic Dermatitis on Osteoporosis and Osteopenia
Using Mendelian randomization to analyze the causal effect of AD on osteoporosis and bone loss. 19 single-nucleotide polymorphisms were detected in Genome-Wide Association Studies (GWASs) database from IEU GWASs Project. The outcomes were Osteoporosis and Osteopenia, the subset differed by bone and age. MR-Egger regression, Inverse variance weighted, weighted median, weighted mode, and simple mode was conducted for MR analyses.
Steps to reproduce
Analyses were implemented by the package TwoSampleMR (version 0.5.6) and MRPRESSO (version 1.0) in R (version 4.3.0) The GAWS summary data for Osteoporosis and low BMD were also obtained from the IEU GWASs Projector, and the GAWS summary data for Age at menopause were obtained from A meta-analysis of GWAS (https://www.reprogen.org/data_download.html)
GK2021 Provincial Natural Fund (21-262)
Zhejiang Province Traditional Chinese Medicine Science and Technology Program for Traditional Chinese Medicine modernization