Data Table of Influence of extended dwell time during pre- and main compression on the properties of ibuprofen.

Published: 6 May 2018 | Version 1 | DOI: 10.17632/drwddcpyn7.1
Contributor(s):

Description of this data

This dataset is related to the manuscript 'Influence of extended dwell time during pre- and main compression on the properties of ibuprofen'.

While the compaction rate in most tableting machines is only determined by the tableting speed, the high speed rotary tableting machine used in this research project (MODUL P, GEA Process Engineering, Halle, Belgium) can adjust and control the dwell time independently from the tableting speed, using an air compensator which allows displacement of the upper (pre-) compression roller. The effect of this machine design on process parameters and tablet properties was investigated using a formulation containing 80% ibuprofen. The granules were compressed into tablets at 250, 500 and 1000 tablets per minute via double compression (pre- and main compression) with or without extended dwell time.

Process parameters and tablet properties were analyzed using Multivariate Data Analysis. Principal Component Analysis (PCA) was performed on the machine settings and logged data obtained from the tableting press and data acquisition system in order to provide an overview of the performed experiments and investigate the correlations between all process variables. A Partial Least Squares (PLS) regression model was developed to explore the correlations between the machine settings and logged data (X) and the tablet properties (Y). The Data Table contains all data used in the Multivariate Data Analysis (tab 'Data Table'), together with a description of the used keys (tab 'Meaning Data Table') and a schematic overview of the performed experiments (tab 'Meaning Exp')

Experiment data files

Related links

This data is associated with the following publication:

Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets

Published in: European Journal of Pharmaceutics and Biopharmaceutics

Latest version

  • Version 1

    2018-05-06

    Published: 2018-05-06

    DOI: 10.17632/drwddcpyn7.1

    Cite this dataset

    Peeters, E.; Silva, A.F.T.; Fonteyne, M.; De Beer, T.; Vervaet, C.; Remon, J.P. (2018), “Data Table of Influence of extended dwell time during pre- and main compression on the properties of ibuprofen.”, Mendeley Data, v1 http://dx.doi.org/10.17632/drwddcpyn7.1

Statistics

Views: 78
Downloads: 10

Institutions

Universiteit Gent

Categories

Pharmaceutical Technology, Tablet, Tableting

Licence

CC BY 4.0 Learn more

The files associated with this dataset are licensed under a Creative Commons Attribution 4.0 International licence.

What does this mean?

This dataset is licensed under a Creative Commons Attribution 4.0 International licence. What does this mean? You can share, copy and modify this dataset so long as you give appropriate credit, provide a link to the CC BY license, and indicate if changes were made, but you may not do so in a way that suggests the rights holder has endorsed you or your use of the dataset. Note that further permission may be required for any content within the dataset that is identified as belonging to a third party.

Report