The Role of TDP-43-APOE4 in Alzheimer’s Disease Pathogenesis Revealed by Brain Organoids

Published: 16 April 2024| Version 1 | DOI: 10.17632/dtbm8h3vxw.1
Contributors:
Liu-Lin Xiong, Wen-Yuan Wang

Description

Our findings clarified that TDP-43 was involved in AD-related phenotype alterations in cooperation with ApoE4 in AD patient-derived brain organoids and first identified the interaction between TDP-43 and APOE4 mRNA, which will provide a more comprehensive understanding of the neurological function of TDP-43 and ApoE4, and offer new insight into the mechanism of AD. The following uploaded data were related to details on target prediction applied in our study.

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Institutions

  • Chinese Academy of Sciences

Categories

Target Identification

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