Disparities in melanoma survival in Asian American and Pacific Islander patients: A Surveillance, Epidemiology, and End Results (SEER) program-based analysis

Published: 3 November 2025| Version 2 | DOI: 10.17632/f2w6fftspm.2
Contributors:
Christopher O'Neill, Lauren Fane, Angela Wei, Raghav Tripathi, Jeremy Bordeaux, Iris Sheng

Description

Although Asian American and Pacific Islander (AAPI) patients are at lower risk for developing melanoma compared to non-Hispanic white (NHW) populations, Asian American and Pacific Islanders (AAPI) have worse survival after melanoma diagnosis compared to non-Hispanic white (NHW) populations. The authors analyzed histologically confirmed cases of cutaneous melanoma in AAPI patients and NHW patients in the specialized Detailed Asian/Pacific Islander Groups Database of the Surveillance, Epidemiology, and End Results program (1992-2022). Cox proportional hazard ratios were utilized to evaluate the association of race and stage on melanoma-specific mortality; hazard ratios were calculated for AAPI patients with NHW patients as the reference group. AAPI patients experience later-stage diagnosis and increased melanoma-specific mortality. Survival disparities remained after adjusting for stage of diagnosis and were present even when AAPI patients were diagnosed at early stages of melanoma.

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Cancer Epidemiology, Melanoma, Racial Disparity, Database

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