Research Data: "Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue"

Published: 14 June 2022| Version 2 | DOI: 10.17632/f38d6s33wm.2
Contributors:
Alba Gonzalez-Franquesa, Pau Gama-Perez, Pablo Garcia-Roves

Description

It includes the different subsets of experimental data corresponding to the original article "Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue" as follows: Table1_Gene expression by rtPCR; normalized gene expression data in different tissues, and statistical test. Table2_Metabolomics data by NMR; normalized metabolite abundance in different tissues, and statistical test. Table3_Hi-Res Respirometry; normalized oxygen flux data and Flux Control Ratios for major respiratory states in different tissues, and statistical test. Table4_Gene expression by RNAseq; variance stabilizing transformed data as determined using DEseq2 for eWAT and Liver. Table5_GOBP-merged terms in the clusters of genes irreversibly decreased with HFD-feeding, from the first intervention and from the second intervention (eWAT). Table6_GOCC-merged terms in the clusters of genes irreversibly decreased with HFD-feeding, from the first intervention and from the second intervention (eWAT). Table 7_Cardiolipidomics by LC-MS/MS; total cardiolipin and monolysocardiolipin abundance, and relative monolysocardiolipin abundance in eWAT. Table8_Proteomics data by LC-MS/MS; Label-Free Quantification (LFQ) intensities for proteins quantified in eWAT. Table9; list of antibodies, TaqMan probes and substrates, uncouplers and inhibitors used, with their corresponding source and reference.

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Categories

Adipose Tissue, Mitochondrion, Metabolism

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