Dataset for 'GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes'

Description

This dataset contains the raw data supporting all main and supplementary figures in the manuscript 'GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes' intended for submission to Neurobiology of Disease. The dataset includes analyses of endolysosomal trafficking and alpha-synuclein pathology in dopaminergic neurons and astrocytes differentiated from iPSCs generated from an individual with Parkinson's disease carrying the GBA1 pathogenic variant GBA1 c.115+1 G>A, also known as IVS2+1 G>A, and an unrelated sex- and age-matched healthy control. The dataset also includes transcriptomic analysis of GBA1 deficient iPSC-neurons and astrocytes compared to GBA1-wildtype iPSC-neurons and astrocytes.

Steps to reproduce

Refer to the Materials and Methods section of the manuscript 'GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes"

Institutions

• VA Puget Sound Health Care System
• University of Washington

Categories

Funders

• National Institute of Neurological Disorders and Stroke

  National Institutes of Health

  United States

  Grant ID: R01 NS119897-01
• National Institute of Neurological Disorders and Stroke

  National Institutes of Health

  United States

  Grant ID: R21 NS118476-01A1
• Parkinson's Foundation

  United States

  Grant ID: PF-CRA-1891
• United States Department of Veterans Affairs

  Government of the United States of America

  United States

  Grant ID: I01CX001702
• John H. Tietze Foundation Trust

  United States

  Grant ID: 2020 John H. Tietze Stem Cell Scientist Award

Licence