DXA-derived visceral adipose tissue and cardiometabolic risk factors in an Algerian adult population
Description
Excess visceral adipose tissue (VAT) promotes insulin resistance and is associated with several chronic conditions, such as hypertension, dyslipidemia, type 2 diabetes, and metabolic syndrome. Data on visceral fat in the Algerian population are lacking. This study aimed to establish reference values for VAT in a general adult population. The secondary objectives were to determine cardio-metabolic consequences and to propose suggested threshold values for VAT to predict metabolic syndrome. Methods We conducted a cross-sectional observational study in a general urban adult population in Algeria. Participants were randomly selected from the electoral list of the municipality of Tlemcen. The required number of subjects for this study was calculated for men and women. Whole-body scans were conducted with a Lunar iDXA (GE Healthcare, USA) DXA scanner. Body composition parameters were analysed using the software enCORE (version 18), and VAT was measured with the CoreScan (GE Healthcare, USA). The other body composition parameters determined are: Subcutaneous adipose tissue, total and regional fat mass, fat mass index, appendicular lean mass index and bone mineral density. Different cardio-metabolic risk factors and other diseases associated with obesity that were assessed. Insulin resistance was assessed with different scores particularly HOMA2-IR score. This database contains other parameters such as physical activity assessed by the GPAQ2 (Global Physical Activity Questionnaire 2) and the Mediterranean diet by the MEDAS and MediLite scores. Results A total of 301 adults (147 men and 154 women) participated. The median (25th-75th percentiles) VAT mass was 1364 g (690-2049) in men and 1060 g (585-1590) in women. Binary logistic regression analyses demonstrated that cardiometabolic risk factors, including hypertension, type 2 diabetes, dyslipidemia, metabolic syndrome, insulin resistance according to HOMA2-IR, hepatic steatosis, and sleep apnea syndrome, were significantly dependent on VAT mass. Threshold values for VAT to predict metabolic syndrome (according to IDF) were ≥ 1369 g in men (sensitivity: 86.2%, specificity: 74.2%, Youden’s index: 0.604) and ≥ 1082 g in women (sensitivity: 76.3%, specificity: 76.9%, Youden’s index: 0.532).
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Institutions
- Universite Abou Bekr Belkaid Tlemcen Faculte de Medecine