Mendeley Data:uv0108
Description
This dataset was generated from a multicenter cross-sectional study that investigated the association between ambient ultraviolet (UV) radiation and dry eye disease (DED) by enrolling 334 patients from four tertiary hospitals in Chengdu (low UV, Sichuan Basin) and Haikou (high UV, tropical island) between November 2024 and November 2025. Comprehensive ocular surface examinations were performed using standardized multimodal imaging, and monthly meteorological data (UV index, temperature, humidity, and wind speed) were obtained for the same period. The data reveal a paradoxical pattern: higher UV exposure was associated with worse subjective symptoms and greater tear film instability, yet paradoxically with less meibomian gland loss—a protective structural association that remained robust after multivariable adjustment (B = −1.94, P < 0.001) and displayed a significant inverse dose-response gradient. Higher humidity and temperature independently contributed to preserved tear film stability and meibomian gland integrity. This dissociation between symptomatic worsening and structural preservation suggests a dual-edged role of UV radiation, with the structural benefit possibly mediated by UV-induced vitamin D synthesis. Users should note that UV exposure is ecological (city-level monthly averages) rather than individually measured, the cross-sectional design precludes causal inference, and individual confounders such as outdoor time and UV protection behaviors were not recorded. The dataset is suitable for meta-analysis, external validation, and hypothesis generation regarding environmental determinants of DED.
Files
Institutions
- Chengdu University of Traditional Chinese MedicineSichuan, Chengdu