Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity. Bowen Jia et al.

Published: 13 August 2025| Version 1 | DOI: 10.17632/fr8zff4ncd.1
Contributors:
Bowen Jia,
,

Description

Material properties of postsynaptic density condensates are governed by multivalent interactions of PSD scaffold proteins. We found in this study that oligomerization of Shank3 is vital to orchestrate molecular organization and PSD material properties, which are directly correlated to synaptic functions. This dataset includes data generated from experiments such as phase separation, neuronal based imaging, and single molecule tracking.

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Institutions

  • Southern University of Science and Technology Department of Biology
  • Hong Kong University of Science and Technology

Categories

Neuroscience, Synaptic Plasticity, Liquid-Liquid Phase Separation

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