Rutin, a flavanol, exerts protective effect against cellular senescence in rats via its senotherapeutic activity

Description

This study investigated the senotherapeutic potential of Rutin in an accelerated senescence model of male Wistar rats based upon parameters linked to suppression of senescence-associated secretory phenotype (SASP), senescence-associated β-galactosidase (SA-β-Gal) activity assay, and modulation of oxidative stress. Accelerated senescence was induced by chronic D-Galactose administration (300mg/kg body weight), and rats were divided into control, Rutin-supplemented, D-Galactose, and Rutin + D-Galactose groups. Treatment of Rutin (100mg/kg body weight) for 28 days significantly suppressed SASP, which includes cytokines such as IL-6 and TNFα, and showed a decline in the number of senescent cells as confirmed by the SA-β-gal assay. Rutin administration also lowered oxidative stress markers, restored antioxidant enzyme activities, and lowered sialic acid levels compared to the D-Galactose-treated group. These results indicate that Rutin mitigates D-Galactose-induced senescence and oxidative damage, highlighting its potential as a senotherapeutic that may delay age-related functional decline.

Institutions

• University of Allahabad

  Uttar Pradesh, Prayagraj

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