Baseline Expression Levels of WNT8B, KRT2, and TTLL13P are associated with abrocitinib response in atopic dermatitis
Published: 15 October 2025| Version 1 | DOI: 10.17632/g6hvm2znjn.1
Contributors:
Yuwen Gao, Yang Luo, Yingxia Gao, Xingyu Chen, Yu Zhang, Yuan Zhou, Beilei Xu, Xu Yao, Xiaochun LiuDescription
Our real-world data from 96 patients confirms that abrocitinib induces rapid clinical improvement and broadly downregulates genes in cytokine and JAK-STAT signaling pathways. We also identified that patients achieving EASI-90 response had a distinct baseline profile characterized by lower Th2 cytokines and a specific transcriptomic signature of high WNT8B and low TTLL13p and KRT2 expression. This signature was validated as a predictive biomarker in an independent cohort, suggesting it can be used to stratify patients for a higher likelihood of achieving minimal disease activity with abrocitinib.
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Institutions
- Chinese Academy of Medical Sciences and Peking Union Medical College
Categories
Dermatology, Atopic Dermatitis, Dermatitis, Eczema
Funders
- National Natural Science Foundation of ChinaChinaGrant ID: 82373489，82330098, 82273542, 82103735, 82304023, 82404151