Periplaneta Americana (L.) extract promotes ischemic stroke recovery by inhibiting inflammasome activation

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Ischemic stroke (IS) remains a devastating cardiovascular disease with high mortality rates and limited treatment options. Current therapeutic approaches face significant challenges in reducing brain injury and promoting neuronal repair post-stroke. While endovascular thrombectomy has shown promise, its narrow treatment window and potential reperfusion injury underscore the urgent need for alternative therapeutic strategies. In this study, we investigate the therapeutic potential of PAS840, an extract from Periplaneta americana (L.), in treating ischemic stroke by examining its components, predicting its targets, and validating its effects on key pathological processes involved in stroke progression.

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