HokB monomerization and membrane repolarization control persister awakening. Wilmaerts et al.

Published: 18 July 2019| Version 2 | DOI: 10.17632/gr3thzhmhp.2
Contributors:
D W, Liselot Dewachter, Pieter-Jan DeLoose, Celien Bollen, Natalie Verstraeten, Jan Michiels

Description

The toxin HokB forms intermolecular disulfide bridges, which are essential for HokB pore formation and consequently the induction of persistence. Additionally, awakening of these persister cells relies on monomerization of the HokB toxin, combined with repolarization of the membrane.

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Institutions

  • Katholieke Universiteit Leuven

Categories

Antibiotics, Western Blot, Correlation Analysis

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