Umbilical cord blood cadmium, lead and mercury in placenta accreta spectrum versus non-accreta pregnancies: a case–control study using detection-limit-aware analysis in Medan, Indonesia
Description
This dataset contains individual-level clinical data from 50 pregnant women who underwent cesarean delivery, divided into two equally sized groups of 25 participants. The grouping variable is coded as 1 and 2, although its column header is currently missing. Based on the available variables, Group 1 appears to represent patients with placenta accreta spectrum (PAS), while Group 2 appears to be a comparison group; this interpretation should be confirmed before analysis. The dataset comprises 56 variables covering: Patient and hospital identification Maternal age, parity, previous cesarean sections, and gestational age Placenta previa and PAS classification Ultrasound markers of PAS Preoperative and postoperative hematological findings Neonatal characteristics and NICU admission Blood-product preparation, transfusion, blood loss, and surgical procedures Blood lead, mercury, and cadmium concentrations Macroscopic cervical involvement and histopathological diagnosis Maternal anthropometric measurements The participants had a mean age of 33.02 years, ranging from 28 to 41 years. Mean gestational age was 37.54 weeks, and the average number of previous cesarean sections was 1.82. Placenta previa was identified in 31 participants. Among the 25 patients with recorded PAS classifications, 7 had PAS 1, 15 had PAS 2, and 3 had PAS 3. Histopathological examination identified 8 cases of placenta accreta, 13 cases of increta, and 4 cases of percreta. The mean estimated blood loss was 863 mL, ranging from 100 to 2,800 mL. The principal surgical procedures were cesarean section alone and cesarean section combined with total abdominal hysterectomy. Neonatal birth weight averaged 2,978.84 g, with a range of 2,450–3,900 g. There were 29 female and 21 male newborns, while 10 newborns were admitted to the NICU. Important data-quality considerations include: The group variable has no column heading. Several clinical and identification variables are systematically missing in Group 2. Preoperative Hb is missing for 25 participants. PAS ultrasound findings and histopathology are available only for Group 1. Many lead and cadmium measurements are expressed as values below the detection limit, such as <5.222, and require appropriate treatment as censored data. Names, national identification numbers, and medical record numbers should be removed before analysis, publication, or external data sharing.
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Steps to reproduce
The data were collected through a hospital-based observational study involving 50 pregnant women, comprising 25 patients with placenta accreta spectrum (PAS) and 25 comparison participants. Maternal characteristics, obstetric history, ultrasound markers, operative findings, neonatal outcomes, and histopathological diagnoses were obtained from clinical records and standardized examinations. Preoperative and postoperative blood samples were analysed for haematological parameters and concentrations of lead, mercury, and cadmium using validated laboratory protocols. The data were coded, checked against the original records, deidentified, and analysed using appropriate statistical software. Replication requires the same eligibility criteria, clinical and laboratory procedures, diagnostic definitions, assay quality-control standards, and statistical workflow.
Institutions
- Universitas Sumatera UtaraNorth Sumatra, Medan