Hydroxytyrosol reduces BPS-induced neuroinflammation by regulating microglia polarization through inhibiting oxidative stress by inactivating of NF-κB signaling pathway

Name: Hydroxytyrosol reduces BPS-induced neuroinflammation by regulating microglia polarization through inhibiting oxidative stress by inactivating of NF-κB signaling pathway
Creator: zhang ZH
Published: 2024-09-24T09:11:18.701Z
Keywords: Toxicology

ZH, zhang; Hou, Yun; Lin, Guoshun

doi:10.17632/hngpdgb82z.1

Hydroxytyrosol reduces BPS-induced neuroinflammation by regulating microglia polarization through inhibiting oxidative stress by inactivating of NF-κB signaling pathway

Published: 24 September 2024| Version 1 | DOI: 10.17632/hngpdgb82z.1

Contributors:

zhang ZH, Yun Hou, Guoshun Lin

Description

This study mainly studied the toxic effect of BPS on microglia, and induced oxidative stress by activating NF-κB signaling pathway to polarize microglia towards M1, inhibit M2 polarization and promote inflammation, thus causing damage to the central nervous system; while hydroxytyrosol treatment reversed the effects of BPS, polarized microglia towards M2, inhibited inflammation. Protects the central nervous system from neuroinflammation.

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Binzhou Medical University - Yantai Campus

Hydroxytyrosol reduces BPS-induced neuroinflammation by regulating microglia polarization through inhibiting oxidative stress by inactivating of NF-κB signaling pathway

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