Supplemental Material for JAAD-D-26-01408 — Risk-Adapted Monitoring of Melanocytic Lesions With Peripheral Globules: A Longitudinal Cohort Study on Melanoma Risk Stratification
Description
This dataset contains the supplemental material for the article "Risk-Adapted Monitoring of Melanocytic Lesions With Peripheral Globules: A Longitudinal Cohort Study on Melanoma Risk Stratification" (Journal of the American Academy of Dermatology; manuscript JAAD-D-26-01408), by Kaan Gündüz, MD; Handan Merve Erol Mart, MD; Ömer Faruk Şimşek, MD; İlay Özsan, MD; Murat Doğuş Günel, MSc; Ayşe Öktem, MD; Bengü Nisa Akay, MD. Per journal policy, supplemental material is hosted here rather than published with the article. Contents: - Supplementary Methods: Full modeling details, including priors, convergence diagnostics, and model-fit metrics. - Supplementary Results: Details of model convergence, patient-level heterogeneity, and out-of-sample predictive performance. - Supplementary Figure 1: Histopathologically confirmed benign melanocytic nevi with peripheral globules. Six lesions (a-f) biopsied or excised because of documented change, age-related concern, growth or persistence of peripheral globules, or clinical caution during digital monitoring; all benign on histopathology. - Supplementary Figure 2: Histopathologically confirmed melanomas presenting with peripheral globules across different age groups. Six lesions (a-f) in patients aged 22 to 78 years, including melanoma in situ and invasive melanomas (Breslow 0.3-0.8 mm), illustrating the role of globule symmetry, size and color variability, associated central structures, and patient-level melanoma risk. - Supplementary Figure 3: Sequential handheld dermoscopic images at baseline, 3 and 6 months of a lesion in a 55-year-old patient with irregular peripheral globules and central asymmetry; excision revealed invasive melanoma (Breslow 0.5 mm). - Supplementary Figure 4: Sequential handheld dermoscopic images at baseline, 3 and 6 months of a lesion in a 22-year-old woman with a family history of melanoma, showing rapid growth and a chaotic dermoscopic pattern; excision revealed invasive melanoma (Breslow 0.45 mm). - Supplementary Table 1: Comparison of lesion-level characteristics between excised and non-excised lesions. - Supplementary Table 2: Secondary analysis restricted to the 143 excised lesions, showing melanoma-specific dermoscopic structures and other independent predictors of adverse histopathologic outcome.
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Institutions
- Ankara UniversityAnkara, Ankara