The Hippo–IGF2 signaling regulates organ growth in development and regeneration
Published: 3 August 2026| Version 1 | DOI: 10.17632/hzvjkjhhvh.1
Contributors:
, Description
Zhong and colleagues reveal a mechanism behind organ size control in development and regeneration. High IGF2 levels drive and coordinate rapid fetal and neonatal growth, while IGF2 silencing —upon postnatal Hippo signaling activation—limits growth and determines organ size. Restoring IGF2 expression enhances tissue repair and reverses age-related regenerative defects.
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Institutions
- Fudan UniversityShanghai, Shanghai
Categories
Stem Cell Regeneration, Hippo Signaling Pathway