Macrophage-Derived IL-23 Drives Intestinal and Hepatobiliary Inflammation Along the Gut-Liver Axis in Primary Sclerosing Cholangitis
Published: 23 July 2026| Version 1 | DOI: 10.17632/j3ph8dr8jh.1
Contributors:
Cristina Di Giorgio, silvia marchianò, , Description
Primary sclerosing cholangitis (PSC) is a gut–liver disease in which intestinal and hepatobiliary inflammation remain therapeutically uncoupled. Although IL-23-directed antibodies improve intestinal inflammation, hepatobiliary benefit is limited. We investigated whether IL-23 belongs to a broader inflammatory circuit and whether dual GPBAR1 agonism/RORγt inverse agonism can interrupt it.
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Institutions
- University of PerugiaUmbria, Perugia
Categories
Inflammation, Primary Sclerosing Cholangitis, Microbiota