Pharmacological Inhibition of LIF Signaling Reverses PD-L1-Mediated Immune Suppression in Gastric Cancer

Published: 12 August 2025| Version 1 | DOI: 10.17632/j46b34szhw.1
Contributors:
Cristina Di Giorgio, silvia marchianò, Michele Biagioli, Stefano Fiorucci

Description

Gastric cancer (GC) is a major clinical challenge, characterized by limited response rates to immune checkpoint inhibitors (ICIs) and persistent immune evasion. Emerging evidence implicates Leukemia Inhibitory Factor (LIF), a cytokine of the IL-6 family, in the modulation of the tumor microenvironment, yet its contribution to PD-L1-mediated immune suppression in GC has not been investigated.

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Institutions

  • Universita degli Studi di Perugia Dipartimento di Medicina

Categories

Cancer, Immunity, Gastric Disease

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