Tumor-Educated Hepatocytes Drive Immune Evasion in Colorectal Cancer Liver Metastasis Through KLK5 Secretion
Description
1.RNA-seq data generated from paired primary colorectal cancer lesions and matched hepatic metastatic lesions obtained from the same patients with colorectal cancer liver metastasis (CRLM). 2.RNA-seq data of THLE-2 cells after co-culture with RKO cells and of control (monocultured) THLE-2 cells. 3. RNA-seq data of RKO cells after co-culture with THLE-2 cells and of control (monocultured) RKO cells. 4. LC–MS data for protein identification in conditioned-medium supernatants from control THLE-2 cells and tumor-educated THLE-2 cells. 5. CRISPR screening for KLK5 substrates. 6. List of sgRNA sequences used for CRISPR screening. 7. LC–MS data for the identification of lysine lactylation sites on PD-L1 protein. 8. LC–MS data for the identification of lysine lactylation sites on PD-L1 protein.
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Institutions
- Fudan UniversityShanghai, Shanghai