Genomic Surveillance of Avian Influenza Virus (H5N1 2.3.4.4b) in Brazil
Description
The complete hemagglutinin (HA) gene sequence obtained in this study was compared with representative H5N1 avian influenza virus (AIV) sequences from Brazil and Colombia available in the GenBank database, including the earliest reported H5N1 sequence from South America. Multiple sequence alignment, phylogenetic reconstruction, and molecular clock analyses consistently placed the virus within clade 2.3.4.4b. To facilitate data sharing and support future evolutionary, epidemiological, and comparative investigations, the assembled HA sequence, together with its associated metadata, including host species, sampling locality, and collection date, was submitted to a publicly accessible nucleotide sequence database.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 2023/01598-9, 2024/09651-9 to PR, 2022/03645-1 to MLN, 2023/14670-0 to CAB, 151207/2023-2, 2023/10809-3 to VGdC, 2023/04491-0 to DBG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - grant number 88887.805202/2023-00 to YLNLG). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - grant number 316593/2023%–0 to CD, nº 405786/2022-0 to FRS). Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS, grant numbers 23/2551-0002221-4 to FRS). INCT Viral Genomic Surveillance and One Health grant 405786/2022-0.
Institutions
- Universidade Estadual Paulista (Unesp)São Paulo, São Paulo