Research Trends in Chronic Obstructive Pulmonary Disease (COPD) Based on Triple Therapy: A Bibliometric Study
Description
Objective: This study explores the evolution, research status and emerging trends in the use of triple therapy for chronic obstructive pulmonary disease (COPD) treatment through bibliometric analysis. Methods: Using a predefined strategy, we gained relevant publications from the Web of Science. Bibliometric and visualization analyses were conducted with VOSviewer and CiteSpace, examining key indicators such as publication counts, authorship, institutions, countries, keywords, and co-citation patterns. Results: A total of 694 articles were analyzed, with a general upward trend in annual publications. The United States had the highest publication output, with GlaxoSmithKline (GSK) as the leading institution. Singh, Dave was the most prolific author, and a core collaborative network was identified between Singh and Lipson, David A. Core keywords included “exacerbation”, “tiotropium”, “asthma” and “lung function”, highlighting the important of research on therapeutic efficacy, clinical outcomes, safety, and adherence. Conclusion: Triple therapy is well-established for COPD treatment, with key research focusing on efficacy, drug combinations, comorbidity management, and patient adherence. Challenges remain in long-term safety monitoring, personalized treatment, and adherence. Future research will focus on biomarker-driven therapies, novel drug development, multidisciplinary strategies, and early interventions to improve treatment outcomes and quality of life for COPD patients.