Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation

Name: Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation
Creator: Yanling Zhang
Published: 2026-08-19T09:07:33.678Z
Keywords: Computational Modeling, Transdermal Drug Transport, Semi-Solid Formulation

Zhang, Yanling; Murthy, S. Narasimha; Rangappa, Srinath; Polak, Sebastian; Paterson, Daniel; Dancik, Yuri; Tabosa, Alice Maciel; Coleman, Lucy; Thakur, Kanika; Tsakalozou, Eleftheria; Ghosh, Priyanka; Clarke, James F.

doi:10.17632/jj5ny3s6mt.1

Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation

Published: 19 August 2026| Version 1 | DOI: 10.17632/jj5ny3s6mt.1

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Description

This dataset contains the Simcyp Simulator V23R2 workspaces and associated data files used to simulate the in vitro and in vivo permeation of clobetasol propionate (CbP) described in the paper "Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation", together with the raw experimental data generated and reported in this work. The experimental data cover in vitro permeation (IVPT), in vitro release (IVRT), skin thickness, skin extraction and surface-wash recovery and formulation characterisation.

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Simcyp (United Kingdom)
England, Sheffield

Funders

United States Food and Drug Administration
United States Department of Health and Human Services
Maryland, Silver Spring

Dermal PBPK modelling of clobetasol propionate cream: Guiding IVPT design and assessing the impact of globule size on skin permeation

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