Online Mindfulness-Based Cognitive Therapy as an Adjuvant-Treatment for Patients with Psoriasis: A Randomized Controlled Trial

Description

To evaluate online Mindfulness-Based Cognitive Therapy (MBCT) as an adjuvant treatment for psoriasis, focusing on severity of lesion, anxiety, depression, quality of life, and itching. This randomized trial enrolled 109 psoriasis patients assigned to either treatment as usual (TAU) or TAU plus MBCT, which included eight weekly online sessions. Primary outcomes, included Psoriasis Area and Severity Index (PASI), Self-Rating Anxiety/Depression Scale (SAS/SDS), and Dermatology Life Quality Index (DLQI). Itching was a secondary outcome measured by Visual Analogue Scale (VAS). Assessments were conducted at baseline, 4, 8, and 12 weeks. Treatment effects were analyzed with mixed linear models. 91 patients completed the full follow-up: 46 in the MBCT+TAU group and 45 in the TAU group. Significant group × time interactions favoring MBCT+TAU were observed for PASI, SDS, DLQI and VAS. No significant between-group difference was found for anxiety.

Steps to reproduce

Statistical analyses were conducted using linear mixed-effects models under the intention-to-treat framework, with per-protocol analyses performed as sensitivity analyses. Detailed analytic procedures are described in the Methods section of the associated article.

Institutions

• First Affiliated Hospital of Xi'an Jiaotong University

  Shaanxi, Xi'an
• Xi'an Jiaotong University

  Shaanxi, Xi'an
• Second Affiliated Hospital of Xi'an Jiaotong University

  Shaanxi, Xi'an

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