GPBAR1-mediated bile acid sensing in cholangiocytes drives IL-23/Th17-dependent inflammation in PSC

Published: 7 November 2025| Version 1 | DOI: 10.17632/jt5zfwshm3.1
Contributors:
Cristina Di Giorgio, silvia marchianò, Michele Biagioli, Stefano Fiorucci

Description

Primary sclerosing cholangitis (PSC) is a progressive cholangiopathy characterized by bile duct inflammation, fibrosis, and increased risk of cholangiocarcinoma. Here we identify the IL-23/IL-17 axis as a central amplifier of PSC and demonstrate that PBT002, an hybrid dual GPBAR1/RORγt ligand, restores immune and metabolic balance in preclinical models.

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Institutions

  • Universita degli Studi di Perugia Dipartimento di Medicina

Categories

Transcriptome, Receptor, Primary Sclerosing Cholangitis, Microbiota

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