Effects of Phyllanthus niruri Extract as a Sheep Feed Additive on Ovine Hepatic and Renal Functions
Description
Microsoft® Translator The description of the data in this study focuses on the effect of Phyllanthus niruri extract as a feed additive on liver and kidney function as well as the hematological profile in sheep. The study involved 24 sheep divided into four treatment groups: a control (feed with 0.5% sodium carboxymethyl cellulose) and three treatment groups with Phyllanthus niruri extract at concentrations of 5% (T1), 10% (T2), and 20% (T3), each given 1 mL per kg of body weight for eight weeks. These data indicate that the administration of Phyllanthus niruri extract at doses of 5%, 10%, and 20% does not cause negative effects on liver and kidney function of sheep, and does not interfere with the hematological profile except for an increase in the number of leukocytes that exhibit immunomodulatory effects. Thus, this extract is safe to use as a feed additive to improve the health and productivity of sheep without the risk of damage to vital organs
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In this study, a randomized complete design was used with 24 male sheep aged 6–8 months. The sheep were randomly assigned to four groups. The first group, the control group (P0), received 0.5% sodium carboxymethyl cellulose (CMC-Na) solution, the second group (P1) 5% Meniran extract, the third group (P2) 10% Meniran extract, and the fourth group (P3) 20% Meniran extract. Each sheep was orally administered 1 mL of Meniran extract daily for eight weeks. Blood samples (3 mL) were collected from each sheep at both the beginning and end of the study to evaluate hematological parameters and clinical chemistry. The blood samples were collected by jugular venipuncture and analyzed for total leukocyte, erythrocyte, and platelet count, lymphocyte percentage, as well as hemoglobin (Hb) and hematocrit (HCT) levels, using an automated hematology analyzer (Pentra C200 Clinical Chemistry Analyzer). Clinical chemistry analyses were performed on hepatic (Serum Glutamic Pyruvic Transaminase [SGPT] and Serum Glutamic Oxaloacetic Transminase [SGOT] and (Blood Urea Nitrogen [BUN] and creatinine) function makers using biochemical kits (Pentra C.200). Data were analyzed using one-way analysis of variance, followed by a Duncan’s post-hoc test for comparisons among groups. Statistical significance was set at p<0.05.
Institutions
- Universitas Airlangga