Proteomics_LuizCaires_PILREV06172020
Published: 24 August 2020| Version 1 | DOI: 10.17632/k78ys98rct.1
Contributors:
Kayque Silva, Description
This work aimed to evaluate the implications of pre-coating rat decellularized liver scaffolds with HepG2-derived conditioned medium (CM) on liver extracellular matrix quality. Our findings suggest that pre-coating improves recellularization, promoting HepG2, endothelial and mesenchymal cells adhension, spreading and proliferation. This proteomics shows LAMB1 and FN1 proteins retention in decellularized livers after HepG2-CM coating, as well as extracellular matrix organization and cell adhension proteins clusterization in coated livers interactome.
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Institutions
Universidade de Sao Paulo, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Categories
Proteomics