TLR4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of GSK-3β in astrocytes
Reactive astrocytes are important pathophysiologically and synthesise neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4-dependent innate immune responses.
National Natural Science Foundation of China
81973503 & 82174001
Natural Science Foundation of Fujian Province
2019J01345, 2020J01727 & 2021J02014