TLR4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of GSK-3β in astrocytes

Published: 13 October 2023| Version 1 | DOI: 10.17632/kkyxrp4yxh.1
Contributors:
Lai Wenfang, Siying Huang, Junjie Liu, Binbin Zhou, Zhengshuang Yu, John Brown, Guizhu Hong

Description

Reactive astrocytes are important pathophysiologically and synthesise neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4-dependent innate immune responses.

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Institutions

Fujian University of Traditional Chinese Medicine

Categories

Astrocyte

Funding

National Natural Science Foundation of China

81973503 & 82174001

Natural Science Foundation of Fujian Province

2019J01345, 2020J01727 & 2021J02014

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